Plenary Sessions I-IV

Plenary Sessions I-IV are a showcase of submitted abstracts that the Scientific Program Chairs and organizers felt were the most representative of the most cutting edge science, reflect a diversity of topics and speakers, and was scored highly amongst the abstract reviewers (among other things).

Each Plenary Session will run for one hour in length and will offer both the talk and a Q&A period immediately afternoon.

PLENARY SESSION I (Tuesday, May 4, 2021) 10:30 am EST – 11:30 am EST

# 693 “Gut Dysbiosis Plays a Role in the Development of Alopecia Areata”

Alexa R. Abdelaziz¹, James Chen¹, Brigitte N. Sallee¹, Eddy H. Wang¹, Zhenpeng Dai¹, Eric Loesch¹, Rolando Perez-Lorenzo¹, Lindsey A. Bordone¹, Angela M. Christiano^{1, 2}

1. Dermatology, Columbia University, New York, NY, United States.
2. Genetics and Development, Columbia University, New York, NY, United States.

# 209 “Epidermal Interferon Production is Positively Regulated by Staphylococcus Aureus in SLE and Involves the STING Pathway”

Sirisha Sirobhushanam¹, Mrinal K. Sarkar¹, helena stickney¹, Josh Banfield¹, Johann E. Gudjonsson¹, Joanne M. Kahlenberg¹

1. University of Michigan, Ann Arbor, MI, United States.

# 646 “Antimicrobial Perforin‐2 in Chronic Wounds Correlates with Healing Outcomes”

Vivien Chen¹, Rivka C. Stone¹, Jamie Burgess¹, Natasa Strbo², Irena Pastar¹, Marjana Tomic-Canic¹

1. Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, United States.
2. Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL, United States.

# 379 “Epidemiology and Risk Factors for the Development of Cutaneous Toxicities in Patients Treated with Immune Checkpoint Inhibitors: A United States Population‐Level Analysis”

Shannon Wongvibulsin^{1, 2}, Vartan Pahalyants¹, Mark Kalinich¹, William Murphy¹, Kun-Hsing Yu³, Feicheng Wang³, Steven Chen¹, Kerry Reynolds⁴, Shawn G. Kwatra², Yevgeniy Semenov¹

1. Dermatology, Massachusetts General Hospital, Boston, MA, United States.
2. Dermatology, Johns Hopkins University, Baltimore, MD, United States.
3. Biomedical Informatics, Harvard Medical School, Boston, MA, United States.
4. Oncology, Massachusetts General Hospital, Boston, MA, United States.

PLENARY SESSION II (Wednesday, May 5, 2021) 10:30 am EST – 11:30 am EST

# 554 “Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans”

Nishadh Sutaria¹, Justin Choi¹, Youkyung S. Roh¹, Kyle A. Williams¹, Martin P. Alphonse¹, Isabelle Brown¹, Thomas Pritchard¹, Natalia Fontecilla Biles¹, Luis A. Garza¹, Sewon Kang¹, Shawn G. Kwatra¹

1. Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

# 598 “Gibbin Toggles CTCF Binding and DNA Methylation to drive Epithelial Development”

Ann Collier¹, Angela Liu^{1, 2}, Jessica Torkelson¹, Jillian Pattison¹, Sadhana Gaddam¹, Tiffany Patel¹, Kelly McCarthy¹, Hanson Zhen¹, Anthony Oro^{1, 2}

1. Program in Epithelial Biology, Stanford University, Stanford, CA, United States.
2. Stem Cell Biology and Regenerative Medicine Graduate Program, Stanford University, Stanford, CA, United States.

# 026 “CXCR4+ Skin‐Resident Natural Killer T cells Participate in Cutaneous Allergic Inflammation in Atopic Dermatitis”

ZhengWang Sun¹, Ji Hye Kim^{1, 2}, Seo Hyeong Kim^{1, 2}, KeLun Zhang^{1, 2}, Hye Li Kim^{1, 2}, Su Min Kim¹, Kwang Hoon Lee^{1, 2, 3}, Thomas S. Kupper⁴, Chang Ook Park^{1, 2, 3}

1. Department of Dermatology, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of).
2. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of).
3. Institute of Allergy, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea (the Republic of).
4. Department of Dermatology & Harvard Skin Disease Research Center, Brigham and Women’s Hospital, Boston, MA, United States.

# 097 “Adipose Triglyceride Lipase Dependent Adipocyte Lipolysis inhibits Dermal Fibrosis”

Elizabeth A. Caves¹, Vivian Lei¹, Valerie Horsley^{1, 2}

1. Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, United States.
2. Dermatology, Yale University School of Medicine, New Haven, CT, United States.

PLENARY SESSION III (Thursday, May 6, 2021) 10:30 am EST – 11:30 am EST

# 079 “Somatic Mutation of the OXA1L 5’UTR enables Cutaneous Squamous Cell Carcinoma”

Angela Mah¹, Jasmine Garcia¹, Dane Sessions¹, Tomas Bencomo¹, Ashley Amado¹, Ankit Srivastava¹, Carolyn Lee^{1, 2}

1. Stanford University, Stanford, CA, United States.
2. VA Palo Alto Health Care System, Palo Alto, CA, United States.

# 439 “Oral 25‐Hydroxyvitamin D3 reduces Chemical‐induced Skin Inflammation in Humans”

Jose-Marc Techner², Robert M. Rothbaum², Luisa Christensen¹, Spencer T. Evans², Ummiye Venus Onay², Dauren Biyashev², Michael Demczuk², Kevin D. Cooper¹, Kurt Lu²

1. Dermatology, University Hospitals, Cleveland, OH, United States.
2. Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

# 114 “Involucrin Deficiency results in Decreased Vitamin D Receptor‐Mediated Inflammation and Csnk1e Isoform Bias”

Alina D. Schmidt¹, Mary Mathyer¹, Erin Brettmann¹, Cristina de Guzman Strong¹

1. Dermatology, Washington University in St Louis School of Medicine, St Louis, MO, United States.

# 487 “Topical MEK Inhibition as Precision Targeted Chemoprevention”

Brittney Sell¹, Jahanbanoo Shahryari^{3, 2}, Aatman Shah², Matthew Duncton³, Wenchao Sun², Peter Fenn³, Scott Plotkin⁴, John Kincaid³, Kavita Y. Sarin², Kenneth Y. Tsai¹

1. Moffitt Cancer Center, Tampa, FL, United States.
2. Stanford University, Stanford, CA, United States.
3. NFlection Therapeutics, Wayne, PA, United States.
4. Massachusetts General Hospital, Boston, MA, United States.

PLENARY SESSION IV (Saturday, May 8, 2021) 10:30 am EST – 11:30 am EST

# 532 “Keratinocyte Desmoglein 1 as a Target and Mediator of Paracrine Signaling in the Melanoma Niche”

Hope Burks¹, Christopher Arnette¹, Jennifer Koetsier¹, Joshua Broussard^{1, 2}, Quinn Roth-Carter¹, Pedram Gerami^{1, 2, 3}, Jodi L. Johnson¹, Kathleen Green^{1, 2, 3}

1. Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
2. Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
3. Robert H Lurie Comprehensive Cancer Center, Chicago, IL, United States.

# 093 “Dissecting Intercellular Communication in Adult Human Skin with Single‐Cell and Spatial Transcriptomics”

Andrew Ji¹, Kim Thrane², Margaret Guo¹, Adam Rubin¹, Daniel Kim¹, Tyler Hollmig¹, Sumaira Aasi¹, Joakim Lundeberg², Paul Khavari¹

1. Dermatology, Stanford University School of Medicine, Stanford, CA, United States.
2. SciLifeLab, Stockholm, Sweden.

# 184 “Whole‐Transcriptome Analysis by RNA‐Seq for Genetic Diagnosis of Mendelian Skin Disorders in the context of Consanguinity”

Leila Youssefian¹, Amir Hossein Saeidian¹, Paolo Fortina¹, Andrew South¹, Jouni Uitto¹, Hassan Vahidnezhad¹

1. Thomas Jefferson University, Philadelphia, PA, United States.
# 499 “Extracellular Vesicles from UVB‐Irradiated Keratinocytes contain Cyclobutane Pyrimidine Dimers”

M A. Carpenter¹, Meghana Ginugu¹, Michael G. Kemp¹

1. Pharmacology and Toxicology, Wright State University, Dayton, OH, United States.

Plenary Sessions I-IV

Other Speakers